PUBLICATIONS

2020

89.  Gassner FJ, Zaborsky N, Buchumenski I, Levanon EY, Gatterbauer M, Schubert M, Stefanie Rauscher S, Hebenstreit D, Nadeu F, Campo E, Egle A,  Greil R,  Geisberger R.

RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia

Leukemia  2020

88.  Hanan  M, Alon Simchovitz A, Yayon N, Vaknine S, Cohen‐Fultheim R, Karmon M, Madrer N, Rohrlich TM,  Maman M, Bennett ER,  Greenberg DS, Meshorer E, Levanon EY, Soreq H, Kadener S 

A Parkinson's disease CircRNA s Resource reveals a link between circSLC 8A1 and oxidative stress

EMBO Molecular Medicine 2020

87.  Schaffer AA*Eli Kopel E*,Hendel A, Picardi E, Levanon EY*,Eisenberg E* 

The cell line A-to-I RNA editing catalogue

Nucleic Acid Research 2020

86.  Barak M, Porath HT, Finkelstein G, Knisbacher BA, Buchumenski I, Roth SH, Levanon EY*, Eisenberg E*

Purifying selection of long dsRNA is the first line of defense against false activation of innate immunity

Genome Biology 2020

85.  Schaffer AA,  Levanon EY

ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions

Methods in Molecular Biology 2020

84.  Cohen-Fultheim R, Levanon EY

Detection of A-to-I Hyper-edited RNA Sequences

Methods in Molecular Biology 2020

2019

83.  Roth SH ,Levanon EYEisenberg E

Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity

Nature Methods 2019

82.  Ishizuka JJ, Manguso RT, Cheruiyot CJ, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP,Yates KB, Dubrot J,Buchumenski I ,Comstock DE,Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ,Griffin GK, Collins NB,Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.

Loss of the RNA editing enzyme ADAR1 in tumors improves response to immunotherapy and overcomes therapeutic resistance. 

Nature 2019

81.  Denichenko P, Mogilevsky M, Cléry A, Welte T, Biran J, Shimshon O, Barnabas GD, Danan-Gotthold M, Kumar S, Yavin E, Levanon EY, Allain FH, Geiger T, Levkowitz G, Karni R.

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides.

Nature communications  2019

80.  Porath HT, Hazan E, Shpigler H, Cohen M, Band M, Ben-Shahar Y, Levanon EY, Eisenberg E, Bloch G.

RNA editing is abundant and correlates with task performance in a social bumblebee

Nature communications  2019

79.  Esposito A, Falace A, Wagner M, Gal M, Mei D, Conti V, Pisano T, Aprile D, Cerullo MS, De Fusco A, 

Giovedì S, Seibt A, Magen D, Polster T, Eran A, Stenton SL, Fiorillo C, Ravid S, Mayatepek E, Hafner H, SWortmann S, Levanon EY, Marini C, Mandel H, Benfenati F, Distelmaier F, Fassio A, Guerrini R

Biallelic DMXL2 mutations impair autophagy and cause Ohtahara syndrome with progressive course

Brain  2019

78.  Dick A L.W, Khermesh K, Paul EE, Stamp F, Levanon EY, Chen A

Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice.

Frontiers in Psychiatry 2019

77.  Pinto Y, Levanon EY.

Computational approaches for detection and quantification of A-to-I RNA-editing. 

Methods 2019

2018

76.  Gannon HS, Zou T, Kiessling MK, Gao GF, Cai D, Choi PS, Ivan AP, Buchumenski I, Berger AC, Goldstein JT, Cherniack AD, Vazquez F, Tsherniak A, Levanon EY, Hahn WC, Meyerson M.

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.

Nature communications  2018

75.  Eisenberg E, Levanon EY.

A-to-I RNA editing - immune protector and transcriptome diversifier.

Nature Reviews Genetics 2018

74.  Jain M*Mann TD*Stulić M*Rao SPKirsch APullirsch DStrobl XRath CReissig LMoreth KKlein-Rodewald TBekeredjian R,

Gailus-Durner VFuchs HHrabě de Angelis MPablik ECimatti LMartin DZinnanti JGraier WFSibilia MFrank SLevanon EY, Jantsch MF.

RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

The EMBO Journal 2018

73.  Shay Ben-Aroya, Levanon EY.

A-to-I RNA Editing: An Overlooked Source of Cancer Mutations.

Cancer Cell 2018

72.  Roth SH*, Danan-Gotthold M*, Ben-Izhak M, Rechavi G, Cohen CJ, Louzoun Y, Levanon EY.

Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus.

Cell Reports 2018

71.  Jacob-Hirsch J, Eyal E, Knisbacher BA, Roth J, Cesarkas K, Dor C, Farage-Barhom S, Kunik V, Simon AJ, Gal M, Yalon M, Moshitch-Moshkovitz S, Tearle R, Constantini S, Levanon EY, Amariglio N, Rechavi G.

Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders.

Cell Research 2018

70.  Shallev L*, Kopel E*, Feiglin A, Leichner GS, Avni D, Sidi Y, Eisenberg E, Barzilai A, Levanon EY*, Greenberger S*

Decreased A-to-I RNA editing as a source of keratinocytes dsRNA in psoriasis.

RNA 2018

69.  Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N.

ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.

Genome Biology 2018

68.  Pinto Y, Buchumenski I, Levanon EY, Eisenberg E.

Human cancer tissues exhibit reduced A-to-I editing of miRNAs coupled with elevated editing of their targets.

Nucleic Acids Research 2018

2017

67.  Solomon O, Di Segni A, Cesarkas K, Porath HT, Marcu-Malina V, Mizrahi O, Stern-Ginossar N, Kol N, Farage-Barhom S, Glick-Saar E, Lerenthal Y, Levanon EY, Amariglio N, Unger R, Goldstein I, Eyal E, Rechavi G.

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure.

Nature Communications 2017

66.  Liscovitch-Brauer N, Alon S, Porath HT, Elstein B,Unger R, Ziv T, Admon A, Levanon EY, ,Rosenthal, JJC,* Eisenberg E*

Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods

Cell  2017   

65.  Danan-Gotthold M, Levanon EY.

Promoting RNA editing by ADAR attraction.

Genome Biology 2017

64.  Levy O, Knisbacher BA, Levanon EY*, Havlin S*.

Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes.

Science Advances 2017

63.  Porath HT, Knisbacher BA, Eisenberg E*, Levanon EY*.

Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance.

Genome Biology 2017

62.  Porath HT, Schaffer AA, Kaniewska P, Alon S, Eisenberg E, Rosenthal J, Levanon EY*, Levy O*.

A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla.

Molecular Biology and Evolution 2017

61.   Buchumenski I, Bartok O, Ashwal-Fluss R, Pandey V, Porath HT, Levanon EY, Kadener S.

Dynamic hyper-editing underlies temperature adaptation in Drosophila.

PLoS Genetics 2017

60.  Kipper S, Frolov L, Guy O, Pellach M, Glick Y, Malichi A, Knisbacher BA, Barbiro-Michaely E, Avrahami D, Yavets-Chen Y, Levanon EY, Gerber D.

Control and automation of multilayered integrated microfluidic device fabrication.

Lab on a Chip 2017

59.  Gal-Mark N, Shallev L, Sweetat S, Barak M, Billy Li J, Levanon EY, Eisenberg E, Behar O.

Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition   

Scientific Reports 2017

2016 

58.  Danan-Gotthold M, Guyon C, Giraud M, Levanon EY*, Abramson J*

Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells.  

Genome Biology 2016

57.  Li K, Wang L, Knisbacher BA, Xy Q, Levanon EY, Frenkel-Morgenstern M, Tagore S, Fang X,  Wang H, Bazak L, Buchumenski I, Zhao Y, Lövy M, Li X, Han L, Frenkel Z, Beiles A, Cao Y, Wang Z. Nevo E

Transcriptome, genetic editing and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax. 

PNAS 2016 

56.  Pinto Y, Gabay O, Arbiza L, Sams AJ, Keinan A*, Levanon EY*: 

Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity. 

Genome Research 2016

55.  Knisbacher BA, Levanon EY:

DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes. 

Molecular Biology and Evolution 2016

54.  Gal M, Khermesh K, Barak M, Lin M, Lahat H, Reznik Wolf H, Lin M, Pras E, Levanon EY

Expanding preconception carrier screening for the Jewish population using high throughput microfluidics technology and next generation sequencing. 

BMC Medical Genomics 2016

53.  Sapoznik S, Bahar-Shany K, Brand H, Pinto Y, Gabay O, Glick-Saar E, Dor C, Zadok O, Barshack I, Zundelevich A, Gal-Yam EN, Yung Y, Hourvitz A, Korach J, Beiner M, Jacob J, Levanon EY, Barak M, Aviel-Ronen S, Levanon K:

Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis. 

Neoplasia 2016

52.  Gal M, Magen D, Zahran Y, Ravid S, Eran A, Khayat M, Gafni C, Levanon EY*, Mandel H*:

A novel homozygous splice site mutation in NALCN identified in siblings with cachexia, strabismus, severe intellectual disability, epilepsy and abnormal  respiratory rhythm. 

European Journal of Medical Genetics 2016

51.  Khermesh K, D'Erchia AM, Barak M, Annese A, Wachtel C, Levanon EY, Picardi E, Eisenberg E

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease. 

RNA 2016

50.  Knisbacher BA, Gerber D, Levanon EY

DNA Editing by APOBECs: A Genomic Preserver and Transformer. 

Trends in Genetics 2016

2015 

49.  Geula A, Moshitch-Moshkovitz S, Dominissini D, AlFatah Mansour A, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Ben Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S,  Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Rechavi G, Hanna JH:

m6A mRNA Methylation Facilitates Adequate Resolution of Naïve Pluripotency Towards Lineage Priming. 

Science 2015

48.  Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Rodriguez M, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N:

Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. 

Cell Reports 2015

47.  Shamay-Ramot A, Khermesh K, Porath HT, Barak M, Pinto Y, Wachtel C, Zilberberg A, Lerer-Goldshtein T, Efroni S, Levanon EY, Appelbaum L. 

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. 

PLos Genetics 2015

46.  Paz-Yaacov N, Bazak L, Buchumenski I, Porath HT, Danan-Gotthold M, Knisbacher BA, Eisenberg E*, Levanon EY*

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors. 

Cell Reports 2015

45.  Danan-Gotthold M, Golan-Gerstl R, Eisenberg E, Meir K, Karni R*, Levanon EY*:

Identification of recurrent regulated alternative splicing events across human solid tumors. 

Nucleic Acids Research 2015

44.  Knisbacher BA, Levanon EY: 

DNA and RNA editing of retrotransposons accelerate mammalian genome evolution. 

Annals of the New York Academy of Sciences 2015

43.  Alon S, Garrett SC, Levanon EY, Olson S, Graveley BR, Rosenthal JJ, Eisenberg E:

The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing. 

eLIFE 2015

2014  

42.  Liscovitch N, Bazak L, Levanon EY, Chechik G:

Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain. 

RNA Biology 2014

41.  Fang X*, Nevo E*, Han L*, Levanon EY*, Zhao J*, Avivi A*, Larkin D*, Jiang X*, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, et al.:

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. 

Nature Communications 2014

40.  Pinto Y, Cohen HY, Levanon EY:

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome. 

Genome Biology 2014

39.  Bazak L, Haviv A, Barak M, Jacob-Hirsch J, Deng P, Zhang R, Isaacs FJ, Rechavi G, Li JB, Eisenberg E*, Levanon EY*:

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes. 

Genome Research 2014

38.  Porath HT, Carmi S, Levanon EY:

A genome-wide map of hyper-edited RNA reveals numerous new sites.

Hyper-editing

Nature Communications 2014

37.  Bazak L, Levanon EY, Eisenberg E:

Genome-wide analysis of Alu editability. 

Nucleic Acids Research 2014

36.  Levanon EY, Eisenberg E:

Does RNA editing compensate for Alu invasion of the primate genome?

Bioessays 2014

35.  Solomon O, Bazak L, Levanon EY, Amariglio N, Unger R, Rechavi G, Eyal E:

Characterizing of functional human coding RNA editing from evolutionary, structural and dynamic perspectives. 

Proteins: Structure, Function, and Bioinformatics 2014

34.  Gal M, Levanon EY, Hujeirat Y, Khayat M, Pe’er J, Shalev S:

Novel mutation in TSPAN12 leads to autosomal recessive inheritance of congenital vitreoretinal disease with intra-familial phenotypic variability. 

American Journal of Medical Genetics Part A 2014

2013

33.  Lindič N, Budič M, Petan T, Knisbacher BA, Levanon EY, Lovšin N:

Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins. 

Retrovirology 2013

32.  Eisenberg E, Levanon EY:

Human housekeeping genes, revisited. 

Trends in Genetics 2013

2012

31.  Sanjana NE, Levanon EY, Hueske EA, Ambrose JM, Li JB:

Activity-dependent A-to-I RNA editing in rat cortical neurons. 

Genetics 2012

2011

30.  Carmi S, Church GM, Levanon EY:

Large-scale DNA editing of retrotransposons accelerates mammalian genome evolution. 

Nature Communications 2011

29.  Carmi S, Borukhov I, Levanon EY:

Identification of widespread ultra-edited human RNAs. 

PLOS Genetics 2011

2010

28.  Zaranek AW*, Levanon EY*, Zecharia T, Clegg T, Church GM:

A Survey of Genomic Traces Reveals a Common Sequencing Error, RNA Editing, and DNA Editing. 

PLOS Genetics 2010

27.  Paz-Yaacov N, Levanon EY, Nevo E, Kinar Y, Harmelin A, Jacob-Hirsch J, Amariglio N, Eisenberg E, Rechavi G:

Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. 

PNAS 2010

26.  Nicholas A, de Magalhaes JP, Kraytsberg Y, Richfield EK, Levanon EY, Khrapko K:

Age-related gene-specific changes of A-to-I mRNA editing in the human brain. 

Mechanisms of Ageing and Development 2010

25.  Greenberger S*, Levanon EY*, Paz-Yaacov N, Barzilai A, Safran M, Osenberg S, Amariglio N, Rechavi G, Eisenberg E.

Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats. 

BMC Genomics 2010

24.  Eisenberg E, Li JB, Levanon EY:

Sequence based identification of RNA editing sites. 

RNA Biology 2010

2009

23.  Carmi S, Levanon EY, Eisenberg E:

Efficiency of complex production in changing environment. 

BMC Systems Biology 2009

22.  Li JB*, Levanon EY*, Yoon J-K, Aach J, Xie B, Leproust E, Zhang K, Gao Y, Church GM:

Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. 

Science  2009

21.  Barak M*, Levanon EY*, Eisenberg E, Paz N, Rechavi G, Church GM, Mehr R:

Evidence for large diversity in the human transcriptome created by Alu RNA editing. 

Nucleic Acids Research 2009

2008

20.  Lev-Maor G, Ram O, Kim E, Sela N, Goren A, Levanon EY, Ast G:

Intronic Alus influence alternative splicing. 

PLoS Genetics 2008

2007  

19.  Paz N, Levanon EY, Amariglio N, Heimberger AB, Ram Z, Constantini S, Barbash ZS, Adamsky K, Safran M, Hirschberg A, Krupsky M, Ben-Dov I, Cazacu S, Mikkelsen T, Brodie C, Eisenberg E, Rechavi G:

Altered adenosine-to-inosine RNA editing in human cancer. 

Genome Research 2007

18.  Lev-maor G, Sorek R, Levanon EY, Paz N, Eisenberg E, Ast G:

RNA-editing-mediated exon evolution. 

Genome Biology 2007

2006

17.  Neeman Y*, Levanon EY*, Jantsch MF, Eisenberg E:

RNA editing level in the mouse is determined by the genomic repeat repertoire. 

RNA 2006

16.  Levanon EY, Eisenberg E:

Algorithmic approaches for identification of RNA editing sites. 

Brief Functional Genomic Proteomic 2006

15.  Carmi S, Levanon EY, Havlin S, Eisenberg E:

Connectivity and expression in protein networks: proteins in a complex are uniformly expressed. 

Physical Review E 2006

2005

14.  Neeman Y, Dahary D, Levanon EY, Sorek R, Eisenberg E:

Is there any sense in antisense editing? 

Trends in Genetics 2005

13.  Levanon K, Eisenberg E, Rechavi G, Levanon EY:

Letter from the editor: Adenosine-to-inosine RNA editing in Alu repeats in the human genome. 

EMBO Reports 2005

12.  Levanon EY, Hallegger M, Kinar Y, Shemesh R, Djinovic-Carugo K, Rechavi G, Jantsch MF, Eisenberg E, Djinoviccarugo K:

Evolutionarily conserved human targets of adenosine to inosine RNA editing. 

Nucleic Acids Research 2005

11.  Kliger Y, Levanon EY, Gerber D:

From genome to antivirals: SARS as a test tube. 

Drug Discovery Today 2005

10.  Havilio M, Levanon EY, Lerman G, Kupiec M, Eisenberg E:

Evidence for abundant transcription of non-coding regions in the Saccharomyces cerevisiae genome. 

BMC Genomics 2005

9.   Eisenberg E, Nemzer S, Kinar Y, Sorek R, Rechavi G, Levanon EY:

Is abundant A-to-I RNA editing primate-specific?. 

Trends in Genetics 2005

8.   Eisenberg E, Adamsky K, Cohen L, Amariglio N, Hirshberg A, Rechavi G, Levanon EY:

Identification of RNA editing sites in the SNP database. 

Nucleic Acids Research 2005

2004

7.   Hazkani-Covo E, Levanon EY, Rotman G, Graur D, Novik A:

Evolution of multicellularity in Metazoa: comparative analysis of the subcellular localization of proteins in Saccharomyces, Drosophila and Caenorhabditis. 

Cell Biology International  2004

6.   Levanon EY*, Eisenberg E*, Yelin R*, Nemzer S*, Hallegger M, Shemesh R, Fligelman ZY, Shoshan A, Pollock SR, Sztybel D, Olshansky M, Rechavi G, Jantsch MF:

Systematic identification of abundant A-to-I editing sites in the human transcriptome. 

Nature Biotechnology 2004

2003

5.   Levanon EY, Sorek R:

The importance of alternative splicing in the drug discovery process. 

Targets 2003

4.   Kliger Y, Levanon EY:

Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy. 

BMC Microbiology 2003

3.   Eisenberg E, Levanon EY:

Preferential attachment in the protein network evolution. 

Physical Review Letters 2003

2.  Yelin R*, Dahary D*, Sorek R*, Levanon EY*, Goldstein O*, Shoshan A, Diber A, Biton S, Tamir Y, Khosravi R, Nemzer S, Pinner E, Walach S, Bernstein J, Savitsky K, Rotman G:

Widespread occurrence of antisense transcription in the human genome. 

Nature Biotechnology 2003

1.   Eisenberg E, Levanon EY:

Human housekeeping genes are compact. 

Trends in Genetics 2003

Erez Levanon's Lab