PUBLICATIONS

2019

Shalom Hillel RothErez Y. LevanonEli Eisenberg

Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity

Nature Methods 2019

Ishizuka JJ, Manguso RT, Cheruiyot CJ, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP,Yates KB, Dubrot J, Buchumenski I,Comstock DE,Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ,Griffin GK, Collins NB,Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.

Loss of the RNA editing enzyme ADAR1 in tumors improves response to immunotherapy and overcomes therapeutic resistance. 

Nature 2019

Denichenko P, Mogilevsky M, Cléry A, Welte T, Biran J, Shimshon O, Barnabas GD, Danan-Gotthold M, Kumar S, Yavin E, Levanon EY, Allain FH, Geiger T, Levkowitz G, Karni R.

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides.

Nature communications  2019

Porath HT, Hazan E, Shpigler H, Cohen M, Band M, Ben-Shahar Y, Levanon EY, Eisenberg E, Bloch G.

RNA editing is abundant and correlates with task performance in a social bumblebee

Nature communications  2019

 

Alec L. W. Dick, Khen Khermesh, Evan Paul, Fabian Stamp, Erez Y. Levanon, Alon Chen

Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain Regions Is Regulated in Response to Chronic Social Defeat Stress in Mice.

Frontiers in Psychiatry 2019

Pinto Y, Levanon EY.

Computational approaches for detection and quantification of A-to-I RNA-editing. 

Methods 2019

2018

Gannon HS, Zou T, Kiessling MK, Gao GF, Cai D, Choi PS, Ivan AP, Buchumenski I, Berger AC, Goldstein JT, Cherniack AD, Vazquez F, Tsherniak A, Levanon EY, Hahn WC, Meyerson M.

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.

Nature communications  2018

Eisenberg E, Levanon EY.

A-to-I RNA editing - immune protector and transcriptome diversifier.

Nature Reviews Genetics 2018

Mamta Jain*, Mann T*, Maja Stulić*, Shailaja, P Rao, Andrijana Kirsch, Dieter Pullirsch, Xué Strobl, 

Claus Rath, Lukas Reissig, Kristin Moreth, Tanja Klein‐Rodewald, Raffi Bekeredjian, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabě de Angelis, Eleonore Pablik, Laura Cimatti, David Martin, Jelena 

Zinnanti, Wolfgang F Graier, Maria Sibilia, Saša Frank, Levanon EY, Michael F Jantsch

RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

The EMBO Journal 2018

Shay Ben-Aroya, Levanon EY.

A-to-I RNA Editing: An Overlooked Source of Cancer Mutations.

Cancer Cell 2018

Roth SH*, Danan-Gotthold M*, Ben-Izhak M, Rechavi G, Cohen CJ, Louzoun Y, Levanon EY.

Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus.

Cell Reports 2018

Jacob-Hirsch J, Eyal E, Knisbacher BA, Roth J, Cesarkas K, Dor C, Farage-Barhom S, Kunik V, Simon AJ, Gal M, Yalon M, Moshitch-Moshkovitz S, Tearle R, Constantini S, Levanon EY, Amariglio N, Rechavi G.

Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders.

Cell Research 2018

Shallev L*, Kopel E*, Feiglin A, Leichner GS, Avni D, Sidi Y, Eisenberg E, Barzilai A, Levanon EY*, Greenberger S*

Decreased A-to-I RNA editing as a source of keratinocytes dsRNA in psoriasis.

RNA 2018

Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N.

ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.

Genome Biology 2018

Pinto Y, Buchumenski I, Levanon EY, Eisenberg E.

Human cancer tissues exhibit reduced A-to-I editing of miRNAs coupled with elevated editing of their targets.

Nucleic Acids Research 2018

2017

Solomon O, Di Segni A, Cesarkas K, Porath HT, Marcu-Malina V, Mizrahi O, Stern-Ginossar N, Kol N, Farage-Barhom S, Glick-Saar E, Lerenthal Y, Levanon EY, Amariglio N, Unger R, Goldstein I, Eyal E, Rechavi G.

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure.

Nature Communications 2017

Liscovitch-Brauer N, Alon S, Porath HT, Elstein B,Unger R, Ziv T, Admon A, Levanon EY, ,Rosenthal, JJC,* Eisenberg E*

Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods

Cell  2017   

Danan-Gotthold M, Levanon EY.

Promoting RNA editing by ADAR attraction.

Genome Biology 2017

Levy O, Knisbacher BA, Levanon EY*, Havlin S*.

Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes.

Science Advances 2017

Porath HT, Knisbacher BA, Eisenberg E*, Levanon EY*.

Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance.

Genome Biology 2017

Porath HT, Schaffer AA, Kaniewska P, Alon S, Eisenberg E, Rosenthal J, Levanon EY*, Levy O*.

A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla.

Molecular Biology and Evolution 2017

Buchumenski I, Bartok O, Ashwal-Fluss R, Pandey V, Porath HT, Levanon EY, Kadener S.

Dynamic hyper-editing underlies temperature adaptation in Drosophila.

PLoS Genetics 2017

Kipper S, Frolov L, Guy O, Pellach M, Glick Y, Malichi A, Knisbacher BA, Barbiro-Michaely E, Avrahami D, Yavets-Chen Y, Levanon EY, Gerber D.

Control and automation of multilayered integrated microfluidic device fabrication.

Lab on a Chip 2017

Gal-Mark N, Shallev L, Sweetat S, Barak M, Billy Li J, Levanon EY, Eisenberg E, Behar O.

Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition   

Scientific Reports 2017

2016 

Danan-Gotthold M, Guyon C, Giraud M, Levanon EY*, Abramson J*

Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells.  

Genome Biology 2016

Li K, Wang L, Knisbacher BA, Xy Q, Levanon EY, Frenkel-Morgenstern M, Tagore S, Fang X,  Wang H, Bazak L, Buchumenski I, Zhao Y, Lövy M, Li X, Han L, Frenkel Z, Beiles A, Cao Y, Wang Z. Nevo E

Transcriptome, genetic editing and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax. 

PNAS 2016 

Pinto Y, Gabay O, Arbiza L, Sams AJ, Keinan A*, Levanon EY*: 

Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity. 

Genome Research 2016

Knisbacher BA, Levanon EY:

DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes. 

Molecular Biology and Evolution 2016

Gal M, Khermesh K, Barak M, Lin M, Lahat H, Reznik Wolf H, Lin M, Pras E, Levanon EY

Expanding preconception carrier screening for the Jewish population using high throughput microfluidics technology and next generation sequencing. 

BMC Medical Genomics 2016

Sapoznik S, Bahar-Shany K, Brand H, Pinto Y, Gabay O, Glick-Saar E, Dor C, Zadok O, Barshack I, Zundelevich A, Gal-Yam EN, Yung Y, Hourvitz A, Korach J, Beiner M, Jacob J, Levanon EY, Barak M, Aviel-Ronen S, Levanon K:

Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis. 

Neoplasia 2016

Gal M, Magen D, Zahran Y, Ravid S, Eran A, Khayat M, Gafni C, Levanon EY*, Mandel H*:

A novel homozygous splice site mutation in NALCN identified in siblings with cachexia, strabismus, severe intellectual disability, epilepsy and abnormal  respiratory rhythm. 

European Journal of Medical Genetics 2016

Khermesh K, D'Erchia AM, Barak M, Annese A, Wachtel C, Levanon EY, Picardi E, Eisenberg E

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease. 

RNA 2016

Knisbacher BA, Gerber D, Levanon EY

DNA Editing by APOBECs: A Genomic Preserver and Transformer. 

Trends in Genetics 2016

2015 

Geula A, Moshitch-Moshkovitz S, Dominissini D, AlFatah Mansour A, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Ben Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S,  Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Rechavi G, Hanna JH:

m6A mRNA Methylation Facilitates Adequate Resolution of Naïve Pluripotency Towards Lineage Priming. 

Science 2015

Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Rodriguez M, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N:

Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. 

Cell Reports 2015

Shamay-Ramot A, Khermesh K, Porath HT, Barak M, Pinto Y, Wachtel C, Zilberberg A, Lerer-Goldshtein T, Efroni S, Levanon EY, Appelbaum L. 

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. 

PLos Genetics 2015

Paz-Yaacov N, Bazak L, Buchumenski I, Porath HT, Danan-Gotthold M, Knisbacher BA, Eisenberg E*, Levanon EY*

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors. 

Cell Reports 2015

Danan-Gotthold M, Golan-Gerstl R, Eisenberg E, Meir K, Karni R*, Levanon EY*:

Identification of recurrent regulated alternative splicing events across human solid tumors. 

Nucleic Acids Research 2015

Knisbacher BA, Levanon EY: 

DNA and RNA editing of retrotransposons accelerate mammalian genome evolution. 

Annals of the New York Academy of Sciences 2015

Alon S, Garrett SC, Levanon EY, Olson S, Graveley BR, Rosenthal JJ, Eisenberg E:

The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing. 

eLIFE 2015

2014  

Liscovitch N, Bazak L, Levanon EY, Chechik G:

Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain. 

RNA Biology 2014

Fang X*, Nevo E*, Han L*, Levanon EY*, Zhao J*, Avivi A*, Larkin D*, Jiang X*, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, et al.:

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. 

Nature Communications 2014

Pinto Y, Cohen HY, Levanon EY:

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome. 

Genome Biology 2014

Bazak L, Haviv A, Barak M, Jacob-Hirsch J, Deng P, Zhang R, Isaacs FJ, Rechavi G, Li JB, Eisenberg E*, Levanon EY*:

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes. 

Genome Research 2014

Porath HT, Carmi S, Levanon EY:

A genome-wide map of hyper-edited RNA reveals numerous new sites.

Hyper-editing

Nature Communications 2014

Bazak L, Levanon EY, Eisenberg E:

Genome-wide analysis of Alu editability. 

Nucleic Acids Research 2014

Levanon EY, Eisenberg E:

Does RNA editing compensate for Alu invasion of the primate genome?

Bioessays 2014

Solomon O, Bazak L, Levanon EY, Amariglio N, Unger R, Rechavi G, Eyal E:

Characterizing of functional human coding RNA editing from evolutionary, structural and dynamic perspectives. 

Proteins: Structure, Function, and Bioinformatics 2014

Gal M, Levanon EY, Hujeirat Y, Khayat M, Pe’er J, Shalev S:

Novel mutation in TSPAN12 leads to autosomal recessive inheritance of congenital vitreoretinal disease with intra-familial phenotypic variability. 

American Journal of Medical Genetics Part A 2014

2013

Lindič N, Budič M, Petan T, Knisbacher BA, Levanon EY, Lovšin N:

Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins. 

Retrovirology 2013

Eisenberg E, Levanon EY:

Human housekeeping genes, revisited. 

Trends in Genetics 2013

2012

Sanjana NE, Levanon EY, Hueske EA, Ambrose JM, Li JB:

Activity-dependent A-to-I RNA editing in rat cortical neurons. 

Genetics 2012

2011

Carmi S, Church GM, Levanon EY:

Large-scale DNA editing of retrotransposons accelerates mammalian genome evolution. 

Nature Communications 2011

Carmi S, Borukhov I, Levanon EY:

Identification of widespread ultra-edited human RNAs. 

PLOS Genetics 2011

2010

Zaranek AW*, Levanon EY*, Zecharia T, Clegg T, Church GM:

A Survey of Genomic Traces Reveals a Common Sequencing Error, RNA Editing, and DNA Editing. 

PLOS Genetics 2010

Paz-Yaacov N, Levanon EY, Nevo E, Kinar Y, Harmelin A, Jacob-Hirsch J, Amariglio N, Eisenberg E, Rechavi G:

Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. 

PNAS 2010

Nicholas A, de Magalhaes JP, Kraytsberg Y, Richfield EK, Levanon EY, Khrapko K:

Age-related gene-specific changes of A-to-I mRNA editing in the human brain. 

Mechanisms of Ageing and Development 2010

Greenberger S*, Levanon EY*, Paz-Yaacov N, Barzilai A, Safran M, Osenberg S, Amariglio N, Rechavi G, Eisenberg E.

Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats. 

BMC Genomics 2010

Eisenberg E, Li JB, Levanon EY:

Sequence based identification of RNA editing sites. 

RNA Biology 2010

2009

Carmi S, Levanon EY, Eisenberg E:

Efficiency of complex production in changing environment. 

BMC Systems Biology 2009

Li JB*, Levanon EY*, Yoon J-K, Aach J, Xie B, Leproust E, Zhang K, Gao Y, Church GM:

Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. 

Science  2009

Barak M*, Levanon EY*, Eisenberg E, Paz N, Rechavi G, Church GM, Mehr R:

Evidence for large diversity in the human transcriptome created by Alu RNA editing. 

Nucleic Acids Research 2009

2008

Lev-Maor G, Ram O, Kim E, Sela N, Goren A, Levanon EY, Ast G:

Intronic Alus influence alternative splicing. 

PLoS Genetics 2008

2007  

Paz N, Levanon EY, Amariglio N, Heimberger AB, Ram Z, Constantini S, Barbash ZS, Adamsky K, Safran M, Hirschberg A, Krupsky M, Ben-Dov I, Cazacu S, Mikkelsen T, Brodie C, Eisenberg E, Rechavi G:

Altered adenosine-to-inosine RNA editing in human cancer. 

Genome Research 2007

Lev-maor G, Sorek R, Levanon EY, Paz N, Eisenberg E, Ast G:

RNA-editing-mediated exon evolution. 

Genome Biology 2007

2006

Neeman Y*, Levanon EY*, Jantsch MF, Eisenberg E:

RNA editing level in the mouse is determined by the genomic repeat repertoire. 

RNA 2006

Levanon EY, Eisenberg E:

Algorithmic approaches for identification of RNA editing sites. 

Brief Functional Genomic Proteomic 2006

Carmi S, Levanon EY, Havlin S, Eisenberg E:

Connectivity and expression in protein networks: proteins in a complex are uniformly expressed. 

Physical Review E 2006

2005

Neeman Y, Dahary D, Levanon EY, Sorek R, Eisenberg E:

Is there any sense in antisense editing? 

Trends in Genetics 2005

Levanon K, Eisenberg E, Rechavi G, Levanon EY:

Letter from the editor: Adenosine-to-inosine RNA editing in Alu repeats in the human genome. 

EMBO Reports 2005

Levanon EY, Hallegger M, Kinar Y, Shemesh R, Djinovic-Carugo K, Rechavi G, Jantsch MF, Eisenberg E, Djinoviccarugo K:

Evolutionarily conserved human targets of adenosine to inosine RNA editing. 

Nucleic Acids Research 2005

Kliger Y, Levanon EY, Gerber D:

From genome to antivirals: SARS as a test tube. 

Drug Discovery Today 2005

Havilio M, Levanon EY, Lerman G, Kupiec M, Eisenberg E:

Evidence for abundant transcription of non-coding regions in the Saccharomyces cerevisiae genome. 

BMC Genomics 2005

Eisenberg E, Nemzer S, Kinar Y, Sorek R, Rechavi G, Levanon EY:

Is abundant A-to-I RNA editing primate-specific?. 

Trends in Genetics 2005

Eisenberg E, Adamsky K, Cohen L, Amariglio N, Hirshberg A, Rechavi G, Levanon EY:

Identification of RNA editing sites in the SNP database. 

Nucleic Acids Research 2005

2004

Hazkani-Covo E, Levanon EY, Rotman G, Graur D, Novik A:

Evolution of multicellularity in Metazoa: comparative analysis of the subcellular localization of proteins in Saccharomyces, Drosophila and Caenorhabditis. 

Cell Biology International  2004

Levanon EY*, Eisenberg E*, Yelin R*, Nemzer S*, Hallegger M, Shemesh R, Fligelman ZY, Shoshan A, Pollock SR, Sztybel D, Olshansky M, Rechavi G, Jantsch MF:

Systematic identification of abundant A-to-I editing sites in the human transcriptome. 

Nature Biotechnology 2004

2003

Levanon EY, Sorek R:

The importance of alternative splicing in the drug discovery process. 

Targets 2003

Kliger Y, Levanon EY:

Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy. 

BMC Microbiology 2003

Eisenberg E, Levanon EY:

Preferential attachment in the protein network evolution. 

Physical Review Letters 2003

Yelin R*, Dahary D*, Sorek R*, Levanon EY*[1], Goldstein O*, Shoshan A, Diber A, Biton S, Tamir Y, Khosravi R, Nemzer S, Pinner E, Walach S, Bernstein J, Savitsky K, Rotman G:

Widespread occurrence of antisense transcription in the human genome. 

Nature Biotechnology 2003

Eisenberg E, Levanon EY:

Human housekeeping genes are compact. 

Trends in Genetics 2003